2025 MLS All-Star Game prediction, odds, start time: MLS vs. Liga MX picks from proven soccer expert
The 2025 MLS All-Star Game features the MLS All-Stars taking on the Liga MX All-Stars at Q2 Stadium in Austin, Texas. This star-studded affair will feature the league's biggest and brightest stars. Lionel Messi headlines the MLS All-Star roster and enters Wednesday's match having scored a brace in six of his last seven league games. However, Messi was absent from Monday's first training session, so his status for the match is in doubt as the MLS side looks to notch its first All-Star Game victory since 2022. The Liga MX All-Star roster features Juan Brunetta, a former Balon de Oro winner, and Sergio Ramos, the legendary former Real Madrid and Spain captain.
Kickoff from Q2 Stadium is set for 9 p.m. ET. Liga MX are the slight +125 favorites (risk $100 to win $125), according to the latest MLS vs. Liga MX odds at bet365. A draw is priced at +320, and the over/under for total goals scored is 3.5. Before locking in any 2025 MLS All-Star Game picks or predictions, you need to see what proven SportsLine's Brandt Sutton has to say. New users at bet365 can get $150 in bonus bets instantly with the latest bet365 bonus code:
Sutton was profitable across multiple leagues for SportsLine subscribers in 2023, including the Champions League, English Premier League, Europa League, FA Cup and more. He also finished 2022 as SportsLine's No. 1 soccer expert with a 165-130-2 mark, returning nearly $2,200 for $100 players. Anyone following his soccer betting picks at sportsbooks could be way up.
Here are Sutton's best bets for MLS All-Stars vs. Liga MX All-Stars on Wednesday:
- Liga MX All-Stars Tie No Bet (-120)
- Half with most goals: 2nd half (-115)
Both teams are expected to make several changes at halftime in order to get everyone playing time, which is the perfect recipe for goals. The lack of continuity between the players will result in more scoring opportunities, which is why I'm backing the second half to feature the most goals scored. Bet this by using the latest BetMGM promo code, where new users can get up to $1500 back in bonus bets if their first bet loses.
Liga MX All-Stars Tie No Bet (-120)The Liga MX All-Stars cruised to a 4-1 victory over the MLS All-Stars last season, and I expect they'll win again on Wednesday. Messi will be the best player on the pitch, but I don't expect him to be on the field for a prolonged period of time, if at all, with Inter Miami chasing its second-straight Supporters' Shield. The MLS side has given up a total of nine goals in their last two appearances in the All-Star Game, and their backline could be exposed by a player like Alexis Vega, who recorded 13 goals and 11 assists to lead Toluca to the 2025 Liga MX Clausura title.
Liga MX All-Stars Tie No Bet is listed at -120 at bet365, where new users can get the latest bet365 bonus code good for $150 in bonus bets with the placement of a $5+ bet. Get started at bet365 here.
Want more soccer picks for Wednesday, July 23?You've seen Brandt Sutton's best bets for the 2025 MLS All-Star Game. Now, get picks for every game from the experts who are tuned into professional soccer leagues all over the world.
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