New coronavirus only ‘one small step from spilling over into humans’ and sparking widespread outbreak, say scientists
A NEW coronavirus may only be "a small step away from spilling over into humans", scientists have warned - sparking fears of another pandemic.
Scientists believe the variant, called HKU5-CoV-2, may infect a broader range of animals than Covid-19 and may have more potential for jumping between species.
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American scientists fear the virus - found in China - may be one small mutation away from also being able to infect humans, which could lead to a widespread outbreak.
The new study, published in Nature Communications, looked at a lesser-known group of coronaviruses called merbecoviruses.
It includes HKU5 and MERS-CoV, which is responsible for the deadly Middle East Respiratory Syndrome.
First noted in 2012, the virus typically spreads from infected camels to humans and causes severe respiratory disease, which can be fatal to 34 per cent of its victims.
The research team, which included scientists at Washington State University (WSU), the California Institute of Technology and the University of North Carolina, sought to understand how merbecoviruses infiltrate the cells of their hosts.
While most bugs in the group seemed to pose little threat to people, scientists said one subgroup, HKU5, has concerning traits.
Michael Letko, a virologist at WSU's College of Veterinary Medicine, said: "Merbecoviruses – and HKU5 viruses in particular – really hadn't been looked at much, but our study shows how these viruses infect cells.
"What we also found is HKU5 viruses may be only a small step away from being able to spill over into humans."
Like other coronaviruses, merbecoviruses rely on a spike protein to bind to receptors and invade host cells.
Dr Letko’s team used virus-like particles containing the part of the spike protein responsible for binding to receptors and tested their ability to infect cells in their lab.
While most merbecoviruses appeared unlikely to be able to infect humans, HKU5 viruses — which have been found across Asia, Europe, Africa and the Middle East — were shown to use a host receptor known as ACE2, the same used by the SARS-CoV-2 virus that causes Covid-19.
But for now HKU5 viruses can only use the ACE2 gene in bats and can't deploy it on humans nearly as well.
Examining HKU5 viruses found in Asia - where their host is the Japanese house bat - the researchers demonstrated some mutations in the spike protein that may allow the viruses to bind to ACE2 receptors in other species, including humans.
“These viruses are so closely related to MERS, so we have to be concerned if they ever infect humans,” Dr Letko said.
“While there’s no evidence they’ve crossed into people yet, the potential is there — and that makes them worth watching.”
Dr Letko said the study and its methods could be used for future research projects and to help the development of new vaccines and treatments.
The new strain - called NB.1.8.1 - has been spotted in the parts of the UK, such as Ireland and Wales.
It's also cropped up in Europe, the US and Australia, as well as Egypt, the Maldives, Thailand, China and Hong Kong.
The World Health Organisation (WHO) recently issued a warning over NB.1.8.1, designating it as a "variant under monitoring" due to its global spread and key mutations.
“Despite a concurrent increase in cases and hospitalisations in some countries where NB.1.8.1 is widespread, current data do not indicate that this variant leads to more severe illness than other variants in circulation,” the WHO said.
But while it may not be particularly severe, it may infect people more easily than previous variants, with some evidence suggesting that the variant binds more tightly to human cells.
A recent study that has not yet been peer reviewed suggests that a person infected with NB.1.8.1 may be more likely to pass the virus on to someone else, compared to earlier variants.
The WHO stressed that, based on available evidence, the variant's risk to public health was "low at the global level".
"Currently approved Covid-19 vaccines are expected to remain effective to this variant against symptomatic and severe disease," it added.
Symptoms include sore throat, fatigue, fever, mild cough, muscle aches and a blocked nose.
Some people may also get gastrointestinal symptoms.
It's not the first time concerns have been raised over HKU5.
Earlier this year, Chinese scientists warned that HKU5-CoV-2 may be able to jump straight from bats to humans without another animal in between.
This suggests a higher potential for zoonotic spillover - when a disease spreads from animal to human.
If there is no 'intermediate middle animal', it becomes harder to predict and prevent spillover events through interactions such as wildlife trading or hunting.
"There is the potential for this new virus to spillover to humans, like previous coronaviruses including SARS-CoV-2," said Dr Gary R McLean, a research fellow at the Imperial College London, who was not involved in the study.
But he noted that, so far, there is no "evidence" that HKU5-CoV-2 can infect people – the paper is based on tests in a laboratory, showing the bug's "potential".
"Hopefully the Chinese authorities now have good surveillance systems in place and the laboratories work to rigid safety standards that minimise the risk of spillover occurring," he said.
The WHO has previously listed MERS and Covid as two of several diseases - alongside the mysterious disease X - that could spark a pandemic, but for which there is no specific treatment or vaccine.
thesun
