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NFL Week 3 betting: Odds, lines and totals for every game

NFL Week 3 betting: Odds, lines and totals for every game
Sep 15, 2025, 02:50 PM ET

Week 3 gets underway with a matchup of AFC East rivals when the Miami Dolphins visit the Buffalo Bills on "Thursday Night Football."

The Bills cruised past the New York Jets in Week 2 to move to 2-0, while the Dolphins dropped to 0-2 after falling to the Patriots in New England.

Not surprisingly, the Bills are the biggest favorite (-13.5) on the Week 3 slate.

Sunday afternoon features two matchups of undefeated teams, with the Philadelphia Eagles (-3.5) hosting the Los Angeles Rams and the Arizona Cardinals hitting the road to face the San Francisco 49ers (-1.5).

"Sunday Night Football" will feature a pair of winless teams: the New York Giants and... the Kansas City Chiefs. The Giants fell to 0-2 after a wild finish in Dallas, and the Chiefs remained winless after a loss to the Eagles in their Super Bowl rematch.

The week wraps up with an enticing "Monday Night Football" matchup, as the Detroit Lions visit the Baltimore Ravens at 8:15 p.m. ET on ABC/ESPN.

Here's a look at the odds for every Week 3 game.

Odds as of publication time. For the most current odds, visit ESPN BET.

Jump to: MIA-BUF | NYJ-TB | IND-TEN | LV-WSH LAR-PHI | ATL-CAR | HOU-JAX | GB-CLE PIT-NE | CIN-MIN | DEN-LAC | NO-SEA ARI-SF | DAL-CHI | KC-NYG | DET-BAL

Miami Dolphins vs. Buffalo Bills -13.5 Thursday, 8:15 p.m., Prime Video

Line movement: Opened Bills -10.5

Money Line: Dolphins (+550); Bills (-900) Total: 49.5; Opened: 48.5 FPI favorite: Bills by 11.1 with a 75.87% probability to win the game outright

New York Jets vs. Tampa Bay Buccaneers -6.5 Sunday, 1 p.m., FOX

Money Line: Jets (+260); Buccaneers (-320) Total: 44.5; Opened: 44.5 FPI favorite: Buccaneers by 7.4 with a 67.51% probability to win the game outright

Indianapolis Colts -3.5 vs. Tennessee Titans Sunday, 1 p.m., CBS

Money Line: Colts (-185); Titans (+155) Total: 43.5; Opened: 43.5 FPI favorite: Colts by 6.2 with a 67.53% probability to win the game outright

Las Vegas Raiders vs. Washington Commanders -5.5 Sunday, 1 p.m., FOX

Money Line: Raiders (+220); Commanders (-270) Total: 46.5; Opened: 47.5 FPI favorite: Commanders by 4.7 with a 62.71% probability to win the game outright

Los Angeles Rams vs. Philadelphia Eagles -3.5 Sunday, 1 p.m., FOX

Money Line: Rams (+160); Eagles (-190) Total: 44.5; Opened: 45.5 FPI favorite: Eagles by 3.1 with a 57.6% probability to win the game outright

Atlanta Falcons -3.5 vs. Carolina Panthers Sunday, 1 p.m., FOX

Money Line: Falcons (-215); Panthers (+180) Total: 43.5; Opened: 44.5 FPI favorite: Falcons by 2.5 with a 57.07% probability to win the game outright

Houston Texans vs. Jacksonville Jaguars -1.5 Sunday, 1 p.m., CBS

Money Line: Texans (+100); Jaguars (-120) Total: 44.5; Opened: 43.5 FPI favorite: Jaguars by 1 with a 52.14% probability to win the game outright

Green Bay Packers -8.5 vs. Cleveland Browns Sunday, 1 p.m., FOX

Money Line: Packers (-450); Browns (+340) Total: 42.5; Opened: 43.5 FPI favorite: Packers by 8.4 with a 70.47% probability to win the game outright

Pittsburgh Steelers -1.5 vs. New England Patriots Sunday, 1 p.m., CBS

Money Line: Steelers (-120); Patriots (+100) Total: 44.5; Opened: 44.5 FPI favorite: Patriots by 0.1 with a 50.33% probability to win the game outright

Cincinnati Bengals vs. Minnesota Vikings -3.5 Sunday, 1 p.m., CBS

Line movement: Opened Vikings -5.5

Money Line: Bengals (+150); Vikings (-175) Total: 41.5; Opened: 44.5 FPI favorite: Vikings by 0.4 with a 51.33% probability to win the game outright

Denver Broncos vs. Los Angeles Chargers -2.5 Sunday, 4:05 p.m., CBS

Money Line: Broncos (+125); Chargers (-145) Total: 45.5; Opened: 46.5 FPI favorite: Chargers by 2.8 with a 56.51% probability to win the game outright

New Orleans Saints vs. Seattle Seahawks -7.5 Sunday, 4:05 p.m., CBS

Money Line: Saints (+300); Seahawks (-400) Total: 41.5; Opened: 42.5 FPI favorite: Seahawks by 5.8 with a 64.2% probability to win the game outright

Arizona Cardinals vs. San Francisco 49ers -1.5 Sunday, 4:25 p.m., FOX

Line movement: Opened Cardinals -1.5

Money Line: Cardinals (+100); 49ers (-120) Total: 44.5; Opened: 43.5 FPI favorite: Cardinals by 0.7 with a 52.33% probability to win the game outright

Dallas Cowboys vs. Chicago Bears -1.5 Sunday, 4:25 p.m., FOX

Money Line: Cowboys (+105); Bears (-125) Total: 49.5; Opened: 49.5 FPI favorite: Cowboys by 1.5 with a 53.13% probability to win the game outright

Kansas City Chiefs -6.5 vs. New York Giants Sunday, 8:20 p.m., NBC

Money Line: Chiefs (-275); Giants (+225) Total: 44.5; Opened: 42.5 FPI favorite: Chiefs by 6.5 with a 66.67% probability to win the game outright

Detroit Lions vs. Baltimore Ravens -5.5 Monday, 8:15 p.m., ABC, ESPN

Money Line: Lions (+210); Ravens (-250) Total: 51.5; Opened: 52.5 FPI favorite: Ravens by 2.4 with a 56.13% probability to win the game outright

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