MRI injections could pose a life-threatening risk

Recent research by specialists at the University of New Mexico has raised concerns about the use of gadolinium, a metal used as a contrast agent in MRI studies. According to the findings, this substance could have serious health consequences for certain patients when it interacts with compounds present in food.

Gadolinium, a toxic element classified as a rare earth element, is widely used to improve the quality of MRI images. Although it is considered safe for most patients, the new study suggests that when combined with oxalic acid (found in foods such as spinach, tomatoes, nuts, and some fruits), it can form tiny metallic particles that accumulate in human organs.

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The research, published in the journal Magnetic Resonance Imaging, examined how these nanoparticles could be linked to serious problems in organs such as the kidneys and brain. Experts also observed its presence in blood and urine even years after the procedure, suggesting a prolonged presence in the body.

One of the diseases associated with these compounds is nephrogenic systemic fibrosis, a rare but serious condition that hardens the skin, lungs, and heart, as well as causing joint stiffness. "There are people who have suffered serious consequences after a single dose," warned Brent Wagner, one of the report's authors.

The scientists focused particularly on oxalic acid, known for its ability to bind metal ions and contribute to the formation of kidney stones. They also noted that this substance can also be produced naturally in the body after consuming foods or supplements containing vitamin C.

During the analysis, it was observed that small amounts of gadolinium can be released from the original contrast agent and form particles that enter cells, triggering potential immune system responses. “When a cell tries to confront a foreign metal nanoparticle that has penetrated its interior, it sends signals to the body to respond,” Dr. Wagner explained.

One of the central questions of the research was why some individuals develop severe symptoms while others do not experience complications. “It could be that they were in a high oxalic acid state or in a state where molecules are more likely to bind to gadolinium, leading to the formation of nanoparticles,” Wagner added.

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In general, when gadolinium is administered, it binds firmly to other molecules in the contrast medium and is eliminated from the body without causing harmful effects in most cases. However, the research team noted that even in patients without symptoms, nanoparticles have been found in brain and kidney tissue, raising new concerns.

As a preventative measure, the study authors suggest avoiding certain supplements before an MRI with contrast. “I wouldn't take vitamin C if I were to have an MRI with contrast because of the metal's reactivity,” Dr. Wagner noted. He also expressed hope that guidelines or concrete solutions will soon be developed to reduce risks in more vulnerable individuals.